Canine Hemangiosarcoma
(Blood Vessel) & Breeds at Risk

Research, Resources & Education

This website is based on research and is NOT created to diagnose your pet. 

Each animal is an individual and may exhibit symptoms in a different way.


It is advised that you ALWAYS CHECK WITH YOUR VETERINARIAN
 for a proper diagnosis and treatment plan.

 

Please visit Lost Temple Fitness & Cancer for more information of cancer in humans including

What is Cancer and Treatments.

Table of Contents

Canine Hemangiosarcoma

Hemangiosarcoma is a cancer that invades blood vessels. When a tumor ruptures, it bleeds into a body cavity like the chest or abdomen.

 

Symptoms Include Weakness, Abdominal distension, Pale mucous membranes and Collapse

 

Hemangiosarcoma typically affects middle-aged to older dogs. Some of the breeds may be predisposed include: Boxers, German Shepherds, Golden Retrievers, Basset Hounds and Dalmatians.

 

Treatments include Surgery, Chemotherapy, Immunotherapy and Radiotherapy 

What Dogs are at Risk?

Some Dogs that are at Risk due to Genetic Predisposition 

Basset Hound
Beagle
Bernese Mountain
Boxer
Dalmatian
Flat Coated Retriever
German Shepherd
Golden Retriever
Greyhound
Italian Greyhound
Labrador Retriever
Pointer
Pit Bull
Portuguese Water
Skye Terrier
Whippet

Hemangiosarcoma Videos

YouTube Videos that help explain Hemangiosarcoma in Dogs.

 

Disclaimer: 
This is for research only and Lost Temple Pets does not endorse any video presented on this website.

 

It is advised that you ALWAYS CHECK WITH YOUR VETERINARIAN for a proper diagnosis and treatment plan.

What is Hemangiosarcoma?

What Is Hemangiosarcoma in Dogs? (PetMD from Chewy)

 

Hemangiosarcoma is an aggressive form of cancer that develops from blood vessels.

  • It can occur anywhere in the body but most often affects a dog’s spleen, heart, liver, or skin.
  • Hemangiosarcoma tumors are composed of abnormal blood and blood vessels that are fragile, invasive, and easily ruptured.
  • When a tumor ruptures, it hemorrhages into a body cavity like the chest or abdomen, causing many of the clinical signs associated with hemangiosarcoma. (PetMD from Chewy)

Hemangiosarcoma (HSA) (National Canine Cancer Foundation)

 

Hemangiosarcoma (HSA) also called malignant hemangioendothelioma or angiosarcoma is deadly cancer that originates in the endothelium and invades the blood vessels.

  • Hemangiosarcoma is more common in dogs than in any other species. It accounts for 5% of all non-cutaneous primary malignant neoplasms and 12% to 21% of all mesenchymal tumors in dogs. 

What are the three types of hemangiosarcomas?

  • Dermal or Cutaneous – Found on the skin
  • Hypodermal or Sub-cutaneous – Found under the skin
  • Visceral or Organ – Found on the spleen, pericardium, and the heart

Other frequent sites include the right atrium, skin and sub-cutis, and liver.

  • Cases have also been reported in the lungs, kidneys, oral cavity, muscle, bone, urinary bladder, left ventricle, uterus, and retroperitoneum.
  • Skin tumors consist of 2.3% to 3.6%.
  • Splenic malignancies account for 45% to 51% and are therefore the most commonly diagnosed and the deadliest. (National Canine Cancer Foundation)

Causes and Genetics

What are the causes of HSA? (National Canine Cancer Foundation)

 

The etiology of this disease is not exactly known. However, its exclusive occurrence in dogs points to the heritable factors that contribute to the risk. Ultimately, the interactions of these risk factors with the environment probably lead to the mutations that give rise to the tumor.

  • Lesions arise when the cell gathers mutations that render the normal constraints of growth and genetic integrity of cells null and void.
  • Mutations take place because the enzymes that control cell division are not foolproof. Some cells in the body divide constantly to replace dead or damaged cells. Therefore, mutations are introduced into the body regularly.
  • Cutaneous hemangiosarcoma (found on the skin) is said to be the result of exposure to sunlight. (National Canine Cancer Foundation)

Are Some Dogs More Susceptible? (AKC)

 

The cause of HSA is not yet known, but there may be a genetic component since it is more commonly diagnosed in certain breeds.

  • Gene studies from dogs with hemangiosarcoma are identifying mutations, with one study showing the most significantly mutated gene to be tumor suppressor TP53, which may appear in certain breeds.
  • According to  Jaime Modianoat the University of Minnesota College of Veterinary Medicine, breeds like Golden Retrievers, Portuguese Water Dogs, Boxers, and German Shepherd Dogs are considered to be at higher risk.
  • “Any dog of any breed, including mixed breeds, and of either sex, regardless of whether it is intact or neutered, can develop hemangiosarcoma,” says Dr. Modiano.

Although HSA is much more common in senior dogs aged between 8 and 12 years, Cornell’s Baker Institute found dogs as young as 2 and as old as 15 were being diagnosed with HSA.

  • “Why dogs are particularly susceptible is unknown, but hemangiosarcoma of the internal organs is very rarely seen in livestock like horses, cows, and goats,” says Sams. On rare occasions, HSA can occur in cats. (AKC)

Symptoms

What are the symptoms? (UF Health – Small Animal College)

 

Clinical signs of HSA are often related to rupture and hemorrhage of the tumor including:

  • Weakness (it can be intermittent)
  • Abdominal distension
  • Pale mucous membranes
  • Collapse

Dogs with tumors involving the right atrium of the heart may present with:

  • Arrhythmias
  • Muffled heart sounds
  • Signs of heart failure

Some dogs may suffer sudden death due to a rupture of a mass in a critical location or severe and acute blood loss into a body cavity.

  • HSA may occur as cutaneous, subcutaneous or deep masses invading or originating from the muscle.
    • These locations may cause lameness, a hard swelling within the muscle or edema of the affected region. (UF Health – Small Animal College)

Testing and Staging

How Veterinarians Diagnose Hemangiosarcoma in Dogs (PetMD from Chewy)

 

Veterinarians may suspect hemangiosarcoma based on clinical signs and history. Because hemangiosarcoma can affect any body system, testing and diagnosis is different based on individual cases.

  • All forms of hemangiosarcoma involve staging, which is a determination of the severity and spread of the disease. Staging will decide available treatment options for pets and develop a general prognosis and expected survival time.
  • Once a veterinarian suspects hemangiosarcoma, they will typically recommend bloodwork, chest x-rays, an abdominal ultrasound, and a cardiac echocardiogram.
  • Advanced imaging, such as a CT scan or MRI, can help figure out the extent of disease spread.

Splenic hemangiosarcoma

  • Veterinarians may diagnose a dog with splenic hemangiosarcoma after an acute collapse episode or weakness after a tumor ruptures. Often, splenic hemangiosarcoma is diagnosed after a veterinarian feels an enlarged spleen or incidentally discovers a mass on the spleen during an x-ray or ultrasound.
  • For a definitive diagnosis, the spleen must be biopsied, and the samples must be evaluated by a pathologist.

Cardiac hemangiosarcoma

  • Heart tumors are usually diagnosed by an ultrasound of the heart, known as an echocardiogram.
  • Veterinarians may suspect a heart tumor after episodes of collapse and other evidence of poor heart function. These tumors may also be discovered incidentally on routine chest x-rays.
  • A biopsy would also be required for a definitive diagnosis, but due to the location of the tumor around the heart, a biopsy is dangerous and typically not recommended.
  • Most cardiac tumors are suspected to be hemangiosarcoma, but few are confirmed.
  • Cardiac hemangiosarcoma is commonly discovered with other types of hemangiosarcoma, most notably of the spleen.
    • During the diagnostic workup process for splenic hemangiosarcoma, veterinarians typically closely evaluate the liver, lungs, and heart, which are all common places for hemangiosarcoma to spread.

Cutaneous/subcutaneous hemangiosarcoma

  • Veterinarians typically start diagnosing skin tumors with a test called a fine needle aspirate (FNA). To perform an FNA, a veterinarian will use a needle to collect a small sample of tumor cells. These cells are then evaluated under a microscope.
  • Some tumors easily shed cells during this process; however, most FNAs performed on hemangiosarcomas are only blood-filled and do not readily offer a diagnosis.
  • A non-diagnostic FNA may raise a veterinarian’s suspicion of cutaneous or subcutaneous hemangiosarcoma.
  • A surgical biopsy is required for a definitive diagnosis. (PetMD from Chewy)

Treatment

What is the treatment for Hemangiosarcoma? (National Canine Cancer Foundation)

 

Surgery remains the primary method of treatment for all dogs with HSA. Cutaneous tumors are curable with surgery alone.

  • But before the surgery appropriate treatment for shock-like crystalloids, colloids and severe coagulation anomalies should be addressed. The surgery here is quite aggressive because all the locally affected tissues have to be removed.
  • For splenic HSAvets go for During the operation, the entire abdomen is thoroughly examined and all the lesions are sent for histopathology.
    • Dogs undergoing this surgery are susceptible to arrhythmia (irregular heartbeats). Thus, post-operation an ECG is needed to monitor the heartbeats of dogs.
    • This issue gets resolved in 24-48 hours.
  • An open or thoracoscopic pericardiectomy is a palliative procedure that allows effusion to escape into the thorax instead of accumulating in the pericardium where a small volume can restrict function.

Other forms of treatment for Hemangiosarcoma include:

Chemotherapy

  • Since a vast majority of the tumors are metastatic, chemotherapy is recommended after the surgery.
  • The standard chemotherapy protocol for Hemangiosarcoma is single-agent and combination doxorubicin, (DOX) intravenously given every 3 weeks.
  • Other combinations used are vincristine, cyclophosphamide and methotrexate, but these have not yielded satisfying results.
  • In cases where surgery is impossible due to the location or the invasiveness of the disease, DOX-based chemotherapy is known to have reduced the gravity of the disease.

Immunotherapy

  • Patients treated with immunotherapy using liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (L-MTP-PE) have shown marked improvement. The drug is not available in the US, but it has gained orphan status in the European Union and is being used in the treatment of pediatric osteosarcoma.

Radiotherapy (RT)

  • It is not so often used due to the high metastatic rate of the disease and the involvement of anatomic sites. A combination of palliative RT with chemotherapy may prove beneficial, but it awaits further investigation. It may prove beneficial in cases like solitary dermal HSA or incomplete resection. (National Canine Cancer Foundation)

References

AKC (American Kennel Club) Hemangiosarcoma in Dogs: What to Know

By Harriet Meyers Updated: Dec 12, 2023

https://www.akc.org/expert-advice/health/hemangiosarcoma-in-dogs/

 

Canine Health Foundation – Canine Hemangiosarcoma – The Road from Despair to Hope

Michelle G. Ritt, DVM, DACVIM; Tessa Breen, BSc (Hons), Dip GD, CMM   08/16/2007

https://www.akcchf.org/canine-health/your-dogs-health/canine-hemangiosarcoma.html

 

National Canine Cancer Foundation – Hemangiosarcoma (HSA) Or Angiosarcoma In Dogs

https://wearethecure.org/learn-more-about-canine-cancer/canine-cancer-library/hemangiosarcoma/

 

Pet MD from Chewy – Hemangiosarcoma in Dogs

By Lauren Jones, VMD Updated Sep. 23, 2022

https://www.petmd.com/dog/conditions/cancer/hemangiosarcoma-dogs

 

UF Health Small Animal College (College for Veterinary Medicine) – Hemangiosarcoma in Dogs

https://smallanimal.vethospital.ufl.edu/clinical-services/oncology/types-of-cancer-and-treatment/hemangiosarcoma-in-dogs/

Cancer/Breed Chart

BREEDBRAINHEMANGIO-
SARCOMA
LYMPHOMAMAMMARY
TUMORS
MAST CELL
TUMOR
MELANOMA
NASAL TUMORORALOSTEOSARCOMAPERIANAL/
ANAL SAC
SOFT TISSUE
SARCOMA
TRANSITIONAL (TCC) / UROTHELIAL (UC)
Airedale TerrierLymphoma MelanomaNasal TumorSoft Tissue SarcomaTCC or UC
Basset HoundHemangiosarcomaLymphoma Nasal TumorSoft Tissue Sarcoma
Bulldog, EnglishBrain Lymphoma Mast Cell TumorPerianal/Anal SacSoft Tissue Sarcoma
BullmastiffLymphoma Mast Cell TumorSoft Tissue Sarcoma
St. BernardLymphoma OsteosarcomaSoft Tissue Sarcoma
Golden RetrieverBrainHemangiosarcomaLymphoma Mast Cell TumorMelanomaOralOsteosarcomaPerianal/Anal SacSoft Tissue Sarcoma
Labrador Retriever HemangiosarcomaLymphoma Mast Cell TumorMelanomaNasal TumorOral
Scottish TerrierBrainLymphoma MelanomaNasal TumorOralSoft Tissue SarcomaTCC or UC
BoxerBrain (Glioma)HemangiosarcomaLymphoma Mammary TumorMast Cell TumorOralOsteosarcomaSoft Tissue Sarcoma
BeagleHemangiosarcomaLymphomaMast Cell TumorPerianal/Anal SacTCC or UC
West Highland White TerrierLymphoma
Chow ChowLymphomaMelanomaOral
Poodle, StandardLymphomaMelanomaNasal TumorOral
RottweilerLymphomaOralOsteosarcoma
Poodle, ToyLymphomaMammary TumorMelanomaNasal Tumor
Yorkshire TerrierLymphomaMammary Tumor
German ShepherdHemangiosarcomaLymphomaMammary TumorMelanomaNasal TumorOralOsteosarcomaPerianal/Anal Sac
Poodle, MiniatureLymphomaMammary TumorMelanomaNasal TumorOral
Affenpinscher
Afghan Hound
Alaskan MalamutePerianal/Anal Sac
American Eskimo, Toy and Standard
American Foxhound
American Pitt Bull TerrierHemangiosarcoma
American Staffordshire Terrier
American Water Spaniel
Anatolian Shepherd Dog
Australian Cattle DogTCC or UC
Australian Shepherd TCC or UC
Australian Terrier
Basenji
Bearded Collie
Beauceron
Bedlington Terrier
Belgian Groenendael
Belgian Malinois
Belgian Tervuren
Bernese Mountain DogHemangiosarcomaMelanomaSoft Tissue Sarcoma
Bichon Frise’TCC or UC
Black and Tan Coonhound
Black Russian Terrier
BloodhoundSoft Tissue Sarcoma
Boerboel
Border CollieBrain TCC or UC
Border Terrier
BorzoiOsteosarcoma
Boston TerrierBrainMast Cell TumorMelanomaSoft Tissue Sarcoma
Bouvier des FlandresSoft Tissue Sarcoma
Briard
Brussels Griffon
Bull TerrierMast Cell TumorMelanoma
Bull Terrier, MiniatureMast Cell TumorMelanoma
Cairn Terrier
Canaan Dog
Cane Corso (Italian Mastiff)
Caucasian Shepherd
Cavalier King Charles SpanielPerianal/Anal Sac
Chesapeake Bay Retriever Melanoma
Chinese Crested
Chinese Shar-PeiMast Cell TumorSoft Tissue SarcomaTCC or UC
Clumber Spaniel
Curly Coated Retriever
DalmationHemangiosarcoma
Dandie Dinmont Terrier
Dogo Argentino
Dogue de Bordeaux
English Foxhound
English Toy Spaniel AKA King Charles Spaniel
Field Spaniel
Finnish Spitz
Flat-Coated RetrieverHemangiosarcoma
Fox Terrier, SmoothMast Cell Tumor
Fox Terrier, ToyMast Cell Tumor
Fox Terrier, WireTCC or UC
French Bulldog
German Pinscher
German Wirehaired Pointer
Glen of Imaal Terrier
Great DaneBrainOsteosarcomaSoft Tissue Sarcoma
Great Pyrenees
Greater Swiss Mountain Dog
GreyhoundBrain (Meningioma)HemangiosarcomaOsteosarcomaSoft Tissue Sarcoma
Harrier
Havanese
Ibizan Hound
Irish Terrier
Irish Water Spaniel
Irish WolfhoundOsteosarcoma
Italian GreyhoundBrain Hemangiosarcoma
Japanese Chin
KeeshondNasal Tumor
Kerry Blue Terrier
Komondor
Kuvasz
Lakeland Terrier
LeonbergerOsteosarcoma
Lhasa ApsoTCC or UC
Lowchen
Manchester Terrier Toy
Manchester Terrier, Standard
MastiffBrain
Miniature Pincher
Neapolitan Mastiff
Newfoundland
Norfolk Terrier
Norwegian Buhund
Norwegian ElkhoundBrainNasal Tumor
Norwich Terrier
Nova Scotia Duck Tolling Retriever
Old English SheepdogBrain
Otterhound
Papillon
Parsons Russell TerrierTCC or UC
PekingeseBrain
Petit Basset Griffon Vendeen (PBGV)
Pharaoh Hound
Plott Hound
Polish Lowland Sheepdog
Pomeranian
Portuguese Water DogBrainHemangiosarcoma
Presa Canario
PugBrainMast Cell TumorSoft Tissue Sarcoma
Puli
Pyrenean Shepherd
Rhodesian RidgebackMast Cell TumorSoft Tissue Sarcoma
Saluki
SamoyedPerianal/Anal Sac
Schipperke
Schnauzer, MiniatureMast Cell TumorMelanomaPerianal/Anal SacSoft Tissue Sarcoma
Schnauzer, StandardMast Cell TumorMelanomaSoft Tissue Sarcoma
Sealyham Terrier
Shiba Inu
Shih TzuBrain
Siberian HuskyPerianal/Anal Sac
Silky Terrier
Skye TerrierHemangiosarcoma
Soft-Coated Wheaten Terrier
Spinone Italiano
Staffordshire Bull TerrierMast Cell Tumor
Sussex Spaniel
Swedish Vallhund
Tibetan Mastiff
Tibetan Spaniel
Tibetan Terrier
Tosa
VizslaMelanoma
WeimaranerMast Cell Tumor
Welsh Corgi, Cardigan
Welsh Corgi, Pembroke
Welsh Springer Spaniel
Welsh Terrier
WhippetHemangiosarcomaTCC or UC
Wirehaired Pointing Griffon
Akita (American)Oral
Collie, Rough / Smooth CoatBrain (Meningioma)Nasal TumorOralTCC or UC
Gordon SetterMelanomaOral
Irish SetterMelanomaOralOsteosarcomaSoft Tissue Sarcoma
Schnauzer, GiantMast Cell TumorMelanomaOral
Scottish DeerhoundBrainMelanomaOralOsteosarcomaTCC or UC
Shetland Sheepdog Nasal TumorOralTCC or UC
BrittanyMammary Tumor
ChihuahuaMammary TumorMelanoma
English Cocker Spaniel Mammary Tumor
English SetterMammary Tumor
English Springer Spaniel Mammary TumorMelanomaPerianal/Anal Sac
MalteseMammary Tumor
PointerHemangiosarcomaMammary Tumor
Cocker Spaniel (American)Mammary TumorMast Cell TumorMelanomaOralPerianal/Anal Sac
DachshundBrain Mammary TumorMast Cell TumorOralPerianal/Anal Sac
Doberman PinscherBrainMammary TumorMelanomaOralOsteosarcoma
German Shorthaired PointerMammary TumorNasal TumorOral
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