Canine Oral Tumor
(Mouth Cancer) & Breeds at Risk

Research, Resources & Education

This website is based on research and is NOT created to diagnose your pet. 

Each animal is an individual and may exhibit symptoms in a different way.


It is advised that you ALWAYS CHECK WITH YOUR VETERINARIAN
 for a proper diagnosis and treatment plan.

 

Please visit Lost Temple Fitness & Cancer for more information of cancer in humans including

What is Cancer and Treatments.

Table of Contents

Oral Tumor

Oral tumors are abnormal growth of cells that occur within the mouth that include skin cells, bone cells and fibrous cells.  The most common types of oral cancer in dogs are Melanoma, Squamous Cell Carcinoma and Oral Fibrosarcoma.

 

Symptoms can include excessive drooling, bad breath, difficulty chewing or drinking,  blood coming from the mouth or loose teeth.  (see symptoms for complete list). 

 

Treatment can include  Surgery, Chemotherapy, Radiation and/or Canine Melanoma Vaccine

What Dogs are at Risk?

Some Dogs that are at Risk due to Genetic Predisposition 

Akita
Boxer
Chow Chow
Cocker Spaniel
Collie
Dachshund
Doberman Pinscher
German Shepherd
Golden Retriever
Gordon Setter
Irish Setter
Labrador Retriever
Pointer
Poodle
Rottweiler
Schnauzer
Scottish Deerhound
Scottish Terrier
Shetland Sheepdog
Weimaraner

Oral Tumors & Types

What is an oral tumor? (VCA Animal Hospital – Overview)

 

An oral tumor is an abnormal growth and unregulated replication of cells that occur within the mouth.

  • A dog’s mouth, similar to our own, is made up of several different cell types; for example, there are epithelial (or skin) cells, bone cells, fibrous cells, and others all of which can become cancerous.
  • Some tumors may grow slowly and do not typically spread, meaning they are benign, whereas others are aggressive and spread elsewhere (malignant tumors). (VCA Animal Hospital – Overview)

What types of cancer can a dog have in their mouth? (First Vet)

 

The most common types of oral cancer in dogs are:

  • Melanoma
  • Squamous cell carcinoma
  • Oral fibrosarcoma

Oral Melanoma in Dogs

Melanoma is a tumor of melanocytes, which are pigment-producing cells of the body.

  • Oral melanoma has been considered an extremely malignant tumor with a high degree of local invasiveness and high metastatic ability.
  • Median survival times for dogs with oral melanoma treated with surgery are approximately 17 to 18, 5 to 6, and 3 months with stage I, II, and III diseases, respectively.
  • The tumors can be pigmented (darkly colored) or non-pigmented (pink like gum tissue). They may appear nodular or cauliflower-like.
    • These tumors are often seen as swellings on the gums around the dog’s teeth or on the soft or hard palate.
    • Melanomas often form ulcers that bleed.
    • Secondary bacterial infection is a common complication.
    • This type of tumor may appear small but they usually extend deeper in the oral tissues and invade the surrounding bone.

Oral Squamous Cell Carcinomas in Dogs

An oral squamous cell carcinoma (SCC) is a malignant tumor affecting the cells that line the throat and mouth, including the tonsils and gum line.

  • It’s the most commonly reported mouth tumor in cats, and the second most common in dogs. Oral SCC in both cats and dogs is locally aggressive, which means it will invade tissues close to the tumor.
  • Bowen’s disease or Bowenoid carcinoma (multicentric carcinoma) is a type of SCC in which the tumors are confined to the surface of the skin and mouth. This type, however, is rare in cats and dogs.
  • The cause of oral SCC has not been identified or fully established, but most experts believe it’s a complex combination of several factors – genetic, environmental, and hereditary.
  • The tumors appear nodular or cauliflower-like and may be pink or discolored.
    • Some tumors break open and bleed.
    • Although they may appear small, these tumors usually extend deeper into the mouth tissues and may invade the underlying bone.

Oral Fibrosarcoma in Dogs

Oral fibrosarcoma’s originate from the fibrous connective tissues of the mouth.

  • These are malignant, rapidly growing tumors. Recurrence is very high after surgery, and metastasis is very common.
  • The tumors may appear as swollen areas within the mouth. They frequently ulcerate and become infected.
  • Surgery to remove the tumor is the standard treatment of choice for fibrosarcoma’s. If adjacent lymph nodes are affected, they are also removed during surgery. (First Vet)

Oral Tumor Videos

YouTube Videos that help explain Osteosarcoma in Dogs

 

Disclaimer: 
This is for research only and Lost Temple Pets does not endorse any video presented on this website.

 

It is advised that you ALWAYS CHECK WITH YOUR VETERINARIAN for a proper diagnosis and treatment plan.

Causes

What causes these types of tumors? (VCA Animal Hospital – Squamous and Melanoma)

 

The reason why a particular dog develops this, or any tumor, is not straightforward.

  • Very few tumors and cancers have a single known cause. Most seem to be caused by a complex mix of risk factors, some environmental and some genetic or hereditary.
  • Male dogs appear to be twice as likely to develop oral cancer than female dogs.
  • In cats, exposure to smoke, as well as the use of flea collars have been identified as significant risk factors for the development of squamous cell carcinoma.
  • In dogs, no such correlation has been made, but may be possible. UV exposure has also been proposed as a risk factor in the development of squamous cell carcinoma of the skin covering the nostrils.

Recent studies have shown that exposure to papilloma-like viruses may contribute to the development of multicentric SCC in the mouth. (VCA Animal Hospital – Squamous and Melanoma)

Symptoms

Symptoms and Types of Oral Cancer in Dogs (PetMD by Chewy)

 

The most common types of oral cancers in dogs are melanoma, squamous cell carcinoma and fibrosarcoma.

They all produce similar symptoms, which generally include some combination of the following:

  • Excessive drooling
  • Bad breath (halitosis)
  • Difficulty chewing (dysphagia) or drinking
  • Blood coming from the mouth
  • Oral pain
  • Weight loss
  • Loose teeth
  • Visible mass in the mouth
  • Enlarged lymph nodes in the neck (occasionally)
  • Swollen or deformed areas on the face (PetMD by Chewy)

What are the clinical signs of squamous cell carcinomas? (VCA Animal Hospital – Squamous)

 

Lesions may appear as diffusely thickened, plaque-like areas, or may be more nodular or cauliflower-like in appearance, arising from any location within the mouth. Others may be associated with the gum line, may be pink or discolored, and may ulcerate (break open and bleed).

  • These tumors may look small but may actually extend deeper into the tissues than expected, invading the underlying bone.
  • Your pet’s clinical signs will depend on the location, tumor type, tumor size, and presence of spread.
  • Oral pain is usually apparent, especially in pets with tumors that have penetrated the underlying bone. This may cause signs such as excessive salivation, excessive panting, bad breath (halitosis), lack of appetite, difficulty eating, and reluctance to be touched on the head.
  • Secondary infections are also common.
  • Swelling of one or both tonsils occurs with tonsillar SCC resulting in difficulty breathing and problems with swallowing. (VCA Animal Hospital – Squamous)

What are the clinical signs of melanoma? (VCA Animal Hospital – Melanomas)

 

Lesions may appear as thickened and pigmented nodules, arising from any location within the mouth. These tumors may look small from the outside but extend deeper into the tissues than expected, invading the underlying bone.

  • Alternately, the bone may be affected first causing significant oral swelling.
  • Oral pain is usually apparent, especially in dogs with tumors that have penetrated the underlying bone.
  • Signs may include bad breath (halitosis), drooling, panting, movement or loss of teeth, bleeding from the teeth, lack of appetite or difficulty eating, reluctance to be touched on the head, facial swelling, and swelling of the lymph nodes. (VCA Animal Hospital – Melanomas)

Testing / Diagnosis

Diagnosis (PetMD by Chewy)

 

As part of a thorough physical examination, your veterinarian will look inside your dog’s mouth for tumors or other abnormalities. This may require sedation.

  • Bloodwork and a urinalysis will provide insight about your dog’s overall health status and are essential to planning appropriate treatment.
  • X-ray images of your dog’s chest may show whether a growth in the mouth has spread to the chest, and a CT scan or MRI of your dog’s mouth may be recommended to determine how invasive the tumor.
  • A tissue biopsy will be taken to determine which kind of cancer is present.
    • In some cases, the entire visible mass can be removed and sent off for identification, but at other times, it’s best to remove just a small piece of the tumor to better plan for future surgery and other necessary treatments.
    • The veterinarian may also want to take a small sample from the lymph nodes to determine whether there are cancerous cells there.

(PetMD by Chewy)

Treatment

Treatment and Prognosis for Dogs with Mouth Cancer (First Vet)

 

Treatment of melanoma is two-pronged – localized treatment of the tumor and systemic treatment because of the high potential for metastasis.

 

Surgery

  • Local control involves surgery to remove the entire tumor. To remove all of the mass, a portion of the bone of the upper or lower jaw may need to be removed. Most dogs do well after surgery without any impact on their quality of life.

Radiation Therapy

  • When surgery is unable to completely remove the oral tumor, radiation therapy is given to help kill any residual disease and decrease or slow down the risk for recurrence.
    • About 75% of patients that undergo radiation therapy experienced a decrease in tumor size depending on the stage of the disease.

Canine Melanoma Vaccine

  • There is a vaccine that is administered once every two weeks for four treatments for dogs with melanoma. A booster vaccine is given once every 6 months after the initial 4 doses.
    • However, the vaccine has its downsides – it can take the dog’s immune system a minimum of 2-3 months before it can mount an adequate immune response that will destroy the melanoma cells.

Chemotherapy

  • Chemotherapy is not recommended because it lacks efficacy. Less than 30% of patients have been shown to respond positively to chemotherapy which is often used for patients with fast-growing or aggressive tumors to slow down the growth and spread and to give time for the vaccine to work. (First Vet)

References

First Vet – Common Types of Oral Cancer in Dogs

https://firstvet.com/us/articles/common-types-of-oral-cancer-in-dogs

 

Merck Vet Manual Oral Tumors in Small Animals

By Alexander M. Reiter, Dipl. Tzt., DEVDC, DAVDC

Reviewed/Revised May 2014

https://www.merckvetmanual.com/digestive-system/diseases-of-the-mouth-in-small-animals/oral-tumors-in-small-animals

 

PetMD by Chewy – Dog Mouth Cancer: Symptoms, Treatment and Life Expectancy

By PetMD Editorial. Reviewed by Jennifer Coates, DVM

Updated Aug. 12, 2022

Reviewed for accuracy on August 19, 2019, by Dr. Jennifer Coates, DVM

https://www.petmd.com/dog/conditions/cancer/c_dg_oral_cavity_tumors

 

VCA Animal Hospital – Melanomas Oral Tumors in Dogs – Melanomas

By Ryan Llera, BSc, DVM; Jan Bellows, DVM, Dipl. AVDC, ABVP; Christopher Pinard, DVM

https://vcahospitals.com/know-your-pet/oral-tumors-in-dogs-melanoma

 

VCA Animal Hospital – Overview – Oral Tumors in Dogs – An Overview

By Malcolm Weir, DVM, MSc, MPH; Jan Bellows, DVM, Dipl. AVDC, ABVP; Christopher Pinard, DVM

https://vcahospitals.com/know-your-pet/oral-tumors-in-dogs-an-overview

 

VCA Animal Hospital – SquamousOral Tumors – Squamous Cell Carcinoma –

By Malcolm Weir, DVM, MSc, MPH; Jan Bellows, DVM, Dipl. AVDC, ABVP; Christopher Pinard, DVM

https://vcahospitals.com/know-your-pet/oral-tumors-squamous-cell-carcinoma

Cancer/Breed Chart

BREEDBRAINHEMANGIO-
SARCOMA
LYMPHOMAMAMMARY
TUMORS
MAST CELL
TUMOR
MELANOMA
NASAL TUMORORALOSTEOSARCOMAPERIANAL/
ANAL SAC
SOFT TISSUE
SARCOMA
TRANSITIONAL (TCC) / UROTHELIAL (UC)
Airedale TerrierLymphoma MelanomaNasal TumorSoft Tissue SarcomaTCC or UC
Basset HoundHemangiosarcomaLymphoma Nasal TumorSoft Tissue Sarcoma
Bulldog, EnglishBrain Lymphoma Mast Cell TumorPerianal/Anal SacSoft Tissue Sarcoma
BullmastiffLymphoma Mast Cell TumorSoft Tissue Sarcoma
St. BernardLymphoma OsteosarcomaSoft Tissue Sarcoma
Golden RetrieverBrainHemangiosarcomaLymphoma Mast Cell TumorMelanomaOralOsteosarcomaPerianal/Anal SacSoft Tissue Sarcoma
Labrador Retriever HemangiosarcomaLymphoma Mast Cell TumorMelanomaNasal TumorOral
Scottish TerrierBrainLymphoma MelanomaNasal TumorOralSoft Tissue SarcomaTCC or UC
BoxerBrain (Glioma)HemangiosarcomaLymphoma Mammary TumorMast Cell TumorOralOsteosarcomaSoft Tissue Sarcoma
BeagleHemangiosarcomaLymphomaMast Cell TumorPerianal/Anal SacTCC or UC
West Highland White TerrierLymphoma
Chow ChowLymphomaMelanomaOral
Poodle, StandardLymphomaMelanomaNasal TumorOral
RottweilerLymphomaOralOsteosarcoma
Poodle, ToyLymphomaMammary TumorMelanomaNasal Tumor
Yorkshire TerrierLymphomaMammary Tumor
German ShepherdHemangiosarcomaLymphomaMammary TumorMelanomaNasal TumorOralOsteosarcomaPerianal/Anal Sac
Poodle, MiniatureLymphomaMammary TumorMelanomaNasal TumorOral
Affenpinscher
Afghan Hound
Alaskan MalamutePerianal/Anal Sac
American Eskimo, Toy and Standard
American Foxhound
American Pitt Bull TerrierHemangiosarcoma
American Staffordshire Terrier
American Water Spaniel
Anatolian Shepherd Dog
Australian Cattle DogTCC or UC
Australian Shepherd TCC or UC
Australian Terrier
Basenji
Bearded Collie
Beauceron
Bedlington Terrier
Belgian Groenendael
Belgian Malinois
Belgian Tervuren
Bernese Mountain DogHemangiosarcomaMelanomaSoft Tissue Sarcoma
Bichon Frise’TCC or UC
Black and Tan Coonhound
Black Russian Terrier
BloodhoundSoft Tissue Sarcoma
Boerboel
Border CollieBrain TCC or UC
Border Terrier
BorzoiOsteosarcoma
Boston TerrierBrainMast Cell TumorMelanomaSoft Tissue Sarcoma
Bouvier des FlandresSoft Tissue Sarcoma
Briard
Brussels Griffon
Bull TerrierMast Cell TumorMelanoma
Bull Terrier, MiniatureMast Cell TumorMelanoma
Cairn Terrier
Canaan Dog
Cane Corso (Italian Mastiff)
Caucasian Shepherd
Cavalier King Charles SpanielPerianal/Anal Sac
Chesapeake Bay Retriever Melanoma
Chinese Crested
Chinese Shar-PeiMast Cell TumorSoft Tissue SarcomaTCC or UC
Clumber Spaniel
Curly Coated Retriever
DalmationHemangiosarcoma
Dandie Dinmont Terrier
Dogo Argentino
Dogue de Bordeaux
English Foxhound
English Toy Spaniel AKA King Charles Spaniel
Field Spaniel
Finnish Spitz
Flat-Coated RetrieverHemangiosarcoma
Fox Terrier, SmoothMast Cell Tumor
Fox Terrier, ToyMast Cell Tumor
Fox Terrier, WireTCC or UC
French Bulldog
German Pinscher
German Wirehaired Pointer
Glen of Imaal Terrier
Great DaneBrainOsteosarcomaSoft Tissue Sarcoma
Great Pyrenees
Greater Swiss Mountain Dog
GreyhoundBrain (Meningioma)HemangiosarcomaOsteosarcomaSoft Tissue Sarcoma
Harrier
Havanese
Ibizan Hound
Irish Terrier
Irish Water Spaniel
Irish WolfhoundOsteosarcoma
Italian GreyhoundBrain Hemangiosarcoma
Japanese Chin
KeeshondNasal Tumor
Kerry Blue Terrier
Komondor
Kuvasz
Lakeland Terrier
LeonbergerOsteosarcoma
Lhasa ApsoTCC or UC
Lowchen
Manchester Terrier Toy
Manchester Terrier, Standard
MastiffBrain
Miniature Pincher
Neapolitan Mastiff
Newfoundland
Norfolk Terrier
Norwegian Buhund
Norwegian ElkhoundBrainNasal Tumor
Norwich Terrier
Nova Scotia Duck Tolling Retriever
Old English SheepdogBrain
Otterhound
Papillon
Parsons Russell TerrierTCC or UC
PekingeseBrain
Petit Basset Griffon Vendeen (PBGV)
Pharaoh Hound
Plott Hound
Polish Lowland Sheepdog
Pomeranian
Portuguese Water DogBrainHemangiosarcoma
Presa Canario
PugBrainMast Cell TumorSoft Tissue Sarcoma
Puli
Pyrenean Shepherd
Rhodesian RidgebackMast Cell TumorSoft Tissue Sarcoma
Saluki
SamoyedPerianal/Anal Sac
Schipperke
Schnauzer, MiniatureMast Cell TumorMelanomaPerianal/Anal SacSoft Tissue Sarcoma
Schnauzer, StandardMast Cell TumorMelanomaSoft Tissue Sarcoma
Sealyham Terrier
Shiba Inu
Shih TzuBrain
Siberian HuskyPerianal/Anal Sac
Silky Terrier
Skye TerrierHemangiosarcoma
Soft-Coated Wheaten Terrier
Spinone Italiano
Staffordshire Bull TerrierMast Cell Tumor
Sussex Spaniel
Swedish Vallhund
Tibetan Mastiff
Tibetan Spaniel
Tibetan Terrier
Tosa
VizslaMelanoma
WeimaranerMast Cell Tumor
Welsh Corgi, Cardigan
Welsh Corgi, Pembroke
Welsh Springer Spaniel
Welsh Terrier
WhippetHemangiosarcomaTCC or UC
Wirehaired Pointing Griffon
Akita (American)Oral
Collie, Rough / Smooth CoatBrain (Meningioma)Nasal TumorOralTCC or UC
Gordon SetterMelanomaOral
Irish SetterMelanomaOralOsteosarcomaSoft Tissue Sarcoma
Schnauzer, GiantMast Cell TumorMelanomaOral
Scottish DeerhoundBrainMelanomaOralOsteosarcomaTCC or UC
Shetland Sheepdog Nasal TumorOralTCC or UC
BrittanyMammary Tumor
ChihuahuaMammary TumorMelanoma
English Cocker Spaniel Mammary Tumor
English SetterMammary Tumor
English Springer Spaniel Mammary TumorMelanomaPerianal/Anal Sac
MalteseMammary Tumor
PointerHemangiosarcomaMammary Tumor
Cocker Spaniel (American)Mammary TumorMast Cell TumorMelanomaOralPerianal/Anal Sac
DachshundBrain Mammary TumorMast Cell TumorOralPerianal/Anal Sac
Doberman PinscherBrainMammary TumorMelanomaOralOsteosarcoma
German Shorthaired PointerMammary TumorNasal TumorOral
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